A Low-Molecular-Weight Ferroxidase Is Increased in the CSF of sCJD Cases: CSF Ferroxidase and Transferrin as Diagnostic Biomarkers for sCJD

Decreased CSF Transferrin in sCJD: A Potential Pre-Mortem Diagnostic Test for Prion Disorders

Sporadic Creutzfeldt-Jakob-disease (sCJD) is a fatal neurodegenerative condition that escapes detection until autopsy. Recently, brain iron dyshomeostasis accompanied by increased transferrin (Tf) was reported in sCJD cases. The consequence of this abnormality on cerebrospinal-fluid (CSF) levels of Tf is uncertain. We evaluated the accuracy of CSF Tf, a 'new' biomarker, as a pre-mortem diagnost...

Progress in CSF biomarker discovery in sCJD

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion diseases caused by the misfolding of the cellular prion protein (PrPc) into its pathogenic form (PrPSc). It is clinically characterized by rapidly progressive dementia leading to the death of the patient usually in less than one year after disease onset. In the brain tissue, spongiform vacuolation, massive neuro...

Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention.

Parkinson's disease is a neurodegenerative disorder characterized by oxidative stress and CNS iron deposition. Ceruloplasmin is an extracellular ferroxidase that regulates cellular iron loading and export, and hence protects tissues from oxidative damage. Using two-dimensional electrophoresis, we investigated ceruloplasmin patterns in the CSF of human Parkinson's disease patients. Parkinson's d...

Diagnostic performance of CSF biomarkers in CJD

CSF Biomarkers

With an ever growing population of aged individuals who are at risk of developing Alzheimer’s disease (AD), there is an urgent need for a sensitive, specific and preferably non-invasive diagnostic standard of disease progression. Diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accura...